An iontophoretic, fentanyl HCl patient-controlled transdermal system for acute postoperative pain management - Chiropractic Treatment

An iontophoretic, fentanyl HCl patient-controlled transdermal system for acute postoperative pain management
June 2005
Jacques E Chelly‌
UPMC Shadyside Hospital, Department of Anesthesiology, Suite M140 (Posner Pain Center), 5230 Centre Avenue, Pittsburgh, PA 15232, USA. ChelJE@anes.upmc.edu
University of Pittsburgh Medical Center, Department of Anesthesiology, Medical Center, Pittsburgh, PA, USA

Patient-controlled modalities using intravenous or epidural routes have dramatically improved postoperative pain management. However, acute post-operative pain continues to be undermanaged. Intravenous patient-controlled analgesia (PCA), the current standard of care for acute postoperative pain management, requires the patient to be attached to a staff-programmed pump apparatus via an intravenous catheter and tubing, rendering it invasive and mobility-limiting. An innovative, needle-free, iontophoretic, fentanyl HCl patient-controlled transdermal system (PCTS) is being developed for acute postoperative pain management. Fentanyl HCl PCTS is a compact, self-contained system that is easily applied to the upper outer arm or chest. It provides pain relief therapeutically equivalent to that of a standard regimen of morphine intravenous PCA, with pharmacokinetics similar to those of intravenous fentanyl infusion. Fentanyl HCl PCTS may be an effective, non-invasive alternative to currently available PCA modalities.

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